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Thursday, April 30, 2020 | History

4 edition of cAMP-dependent protein kinase activity in bipolar affective disorder found in the catalog.

cAMP-dependent protein kinase activity in bipolar affective disorder

Melissa Albin

cAMP-dependent protein kinase activity in bipolar affective disorder

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  • 27 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 2000.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19129020M
ISBN 100612541320
OCLC/WorldCa50754936

Serotonergic studies in patients with affective and personality disorders. Correlates with protein kinase C activity in bipolar affective disorder, manic episode. Biological Psychiatry, 33(7), bipolar disorder. Biological Psychiatry, – Mann, J. J., & Arango, V. (). High-quality St John’s wort extracts have been demonstrated to be effective in the treatment of mild to moderate depression and somatoform disorder, with possible benefits in seasonal affective disorder. However, St John’s wort has also been shown to induce cytochrome P 3A4, 2C9, and 1A2 isozymes and P-glycoproteins in humans. 19 Author: Patricia L. Gerbarg, Richard P. Brown.   Objectives Abnormalities of signal transduction are considered among the susceptibility factors for bipolar disorder (BD). These include changes in G‐protein‐mediated signaling and subsequent modification of gene expression via transcription factors such as cAMP response element‐binding protein (CREB). Methods We investigated levels of CREB in lymphoblasts from . The novel approaches to psychiatric classification assume that disorders, contrary to what was previously thought, are not completely separate phenomena. In this regard, in addition to symptom-based criteria, disturbances are also considered on the basis of lower level components. With this viewpoint, identifying common biochemical markers would be beneficial in adopting a comprehensive.


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cAMP-dependent protein kinase activity in bipolar affective disorder by Melissa Albin Download PDF EPUB FB2

Basal cyclic AMP‐dependent protein kinase activity was also significantly higher (40%) in temporal cortex cytosolic fractions of bipolar disorder brain compared with controls.

Estimated EC 50 values for cyclic AMP activation of this kinase were significantly lower (70 and 58%, respectively) in both cytosolic and particulate fractions of temporal cortex from bipolar disorder subjects Cited by: Altered cAMP-dependent protein kinase subunit immunolabeling in post-mortem brain from patients with bipolar affective disorder.

Journal of Neurochemistry84 (4), DOI: /jx. Darija Lamb, Robert A. by: Background: Abnormalities in cAMP signaling and altered expression of downstream targets such as brain-derived neurotrophic factor (BDNF) have been postulated in patients with bipolar disorder (BD).Methods: The PKA activity and levels of 3 H–cAMP binding to PKA R regulatory subunits were measured in lymphoblasts from 10 BD and 10 control subjects.

In addition, the possibility that BDNF Cited by: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study. The existence of a myocardial Ca 2+ /calmodulin-dependent protein kinase activity was first observed by Le Peuch et al.

and was specified as CaM kinase. Kloepper and Landt [31] identified two Ca 2+ /calmodulin-dependent protein kinase activities in bovine heart, whereas Gupta and Kranias [20] showed that canine myocardium contains only one type Cited by:   Background Abnormalities in the cyclic adenosine monophosphate (cAMP)–dependent phosphorylation system have been recently reported in patients with bipolar disorder.

We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed Cited by:   Karege F, Schwald M, Papadimitriou P, Lachausse C, Cisse M (b) The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder.

J Affect Disord 79(1–3)– PubMed Google ScholarCited by: 2. Abstract. Bipolar affective disorder (BD), or manic-depressive illness, is a chronic, severe, and debilitating mental disorder characterized by episodes of mania or hypomania and depression, which afflicts an estimated 1% of the general population (1).Evidence from family, genetic, and psychobiological studies indicates a major role for biological factors in the genesis, expression, and Cited by: Friedman E, Hoau Yan W, Levinson D, Connell TA, Singh H.

Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biological Psychiatry. ; – Genoux D, Haditsch U, Knobloch M, Michalon A, Storm D, Mansuy IM. Protein phosphatase 1 is a molecular constraint on learning and memory. by:   Fields A, Li PP, Kish SJ, Warsh JJ.

Increased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorder J Neurochem – CAS Cited by: Previous findings of reduced [3H]cAMP binding and increased activities of cAMP-dependent protein kinase (PKA) in discrete post-mortem brain regions from patients with bipolar affective disorder.

Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorder. Biol Psychiatry Sep 1;50(5) "BACKGROUND: Membrane protein kinase C (PKC) activity is increased in frontal cortex of subjects with bipolar affective disorder, and lithium was demonstrated to inhibit PKC translocation to membranes.

PKC activity and change in platelets of patients with mood disorder is in response to protein, which increases the percentage of response in patients with mania, besides it is reduced in patients treated by lithium (5). In rodents, PKC stimulation caused by cocaine stimulus makes the excitation of Cited by:   The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder.

(PMID) PMIDCited by: Protein kinases are used to add phosphate groups to proteins. The one shown here is cAMP-dependent protein kinase, also known as protein kinase A or PKA (PDB entries 3tnp, 1j3h and 2h9r). It is composed of two types of subunits.

The catalytic subunit, shown here in. Juruena, MF Gama, CS Berk, M. and Belmonte-de-Abreu, PS Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series. Journal of Psychopharmacology, Vol. 23, Issue.

8 cAMP-dependent protein kinase activity in major by: In this context, it is interesting to mention that lower [3 H]cAMP binding and greater protein kinase A activity have been reported in the postmortem brain of subjects with bipolar affective disorder. These investigators have speculated that this opposite effect may occur because of the greater relative abundance of free catalytic subunits to regulatory by: Mori and associates have investigated the effects of lithium treatment on cAMP-dependent protein kinase in discrete brain areas of rat by using photoaffinity labeling as well as western blotting.

OBJECTIVE: The purpose of this study was to assess cAMP-dependent protein kinase A in patients with obsessive-compulsive disorder (OCD). METHOD: The levels and the activity of protein kinase A Cited by: cAMP‐dependent protein kinase (PKA) activity in the extracts of Alzheimer disease (AD) and control brains.

(a) PKA activity of the 16 g extract of the medial temporal cortex from six AD and seven age‐matched control brains was assayed in the absence or presence of 5 μmol/L by: In cell biology, protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP).

PKA is also known as cAMP-dependent protein kinase (EC ).Protein kinase A has several functions in the cell, including regulation of BRENDA: BRENDA entry. Tamoxifen is an oral medication that has been proposed as a potential treatment for bipolar disorder. Tamoxifen acts to inhibit the intracellular action of protein kinase C, which is also an action of well-established treatments such as lithium and by: 2.

Alternatively, the changes of PKC activity may be the core pathology of the illness. More studies are required to further characterize the association of PKC changes with bipolar disorder, using a proper neuronal model. PKC Mania Tamoxifen Protein kinases Protein kinase C Bipolar disorders Drugs for bipolars Lithium prophylaxis The manic spectrum.

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci USA –. CAMP-dependent protein kinase activity Antibodies. Antibodies for proteins involved in cAMP-dependent protein kinase activity pathways; according to their Panther/Gene Ontology Classification.

View more View less. Disclaimer. The Science of Mental Health: Bipolar disorder. Anonimo. activity acute adolescents analysis Angst antidepressant-induced antidepressants Arch Gen Psychiatry assessment associated behavior biological bipolar affective disorder bipolar disorder bipolar illness bipolar patients brain carbamazepine cell chromosome chronic lithium circadian.

cAMP-Dependent protein kinase (PKA) subunit mRNA levels in postmortem brain from patients with bipolar affective disorder (BD). (PMID) Abstract Citations and increased immunoreactive levels of PKA regulatory and catalytic subunits in discrete postmortem brain regions from bipolar disorder (BD) patients suggest that disturbances in Cited by: Wang Hy, Freidman E.

Enhanced Protein Kinase C activity and translation in bipolar affective disorder brain. Biol Psychiatry ;40(7) Einat H, Yuan P, Szaho ST, Dogra S, Manji HK.

Protein Kinase C inhibition by tamoxifen antagonizes manic like behavior in rats: Implications for the development of novel therapeutics for bipolar disorders. cAMP is produced by adenylate cyclase in response to G-protein deactivation, it activates many enzymes through cAMP-dependent protein kinase, and it is eliminated through cAMP phosphodiesterase.

cAMP is produced by cAMP phosphodiesterase in response to G-protein activation, it activates many enzymes through cAMP-dependent protein kinase. Bipolar Disorder: Roles of neurotransmitters and signal transduction. words (19 pages) Essay in Psychology. gene cAMP degrades quite quickly in the brain by phosphodiesterase binding of cAMP to another enzyme cAMP-dependent protein kinase (as protein kinase A) is used as an indirect measurement of cAMP.

Protein kinase C (PKC) is a family of enzymes that phosphorylate neurotransmitter receptors, intracellular signaling molecules, transcription factors, and cytoskeletal proteins.

1 Protein kinase C translocates from cytosol to the cell membrane on activation by diacylglycerol or its analogues. Several lines of evidence implicate abnormal PKC activity in bipolar disorder (BPD).Cited by: Bipolar disorder (BD) affects around 3% of the population [] and is a serious multifactorial disease, caused by combination of genetic vulnerability and environmental stressors with abnormalities in neurotransmitter and neuroendocrine systems, and intracellular signaling pathways as ally, BD is characterized by recurrent changes of thought, behavior, cognition, mood, and Cited by: 1.

The bipolar disorder genome has recently identified alterations in diacylglycerol (DAG) kinase eta (DGKH) (21, 22), which encodes for the kinase that normally inhibits DAG activation of PKC signaling. Loss of function of DGKH in bipolar disorder would lead to excessive PKC signaling, as has been reported by: positive regulation of cAMP-dependent protein kinase activity Positive regulation of cAMP-dependent protein kinase activity Antibodies Antibodies for proteins involved in positive regulation of cAMP-dependent protein kinase activity pathways; according to their Panther/Gene Ontology Classification.

Bipolar disorder is a mental disorder characterized by intermittent episodes of mania or depression, with an absence of symptoms in between. During these episodes, people with bipolar disorder exhibit disruptions in normal mood, psychomotor activity-the level of physical activity that is influenced by mood-(e.g., constant fidgeting with mania or slowed movements with depression), circadian Complications: Suicide, self-harm.

Fields A, Li PP, Kish SJ, Warsh JJ () Increased Cyclic AMP-Dependent Protein Kinase Activity in Postmortem Brain from Patients with Bipolar Affective Disorder.

J Neurochem –   The phosphorylation state of this site is dynamic [Kaidanovich-Beilin and Woodgett, ] and regulated by a variety of kinases, including protein kinase B (Akt) [Cross et al.

], cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) [Fang et al. ] and PKC [Fang et al. ], although activation of Akt kinases provide Cited by: A) A cascade of events must occur that ultimately activate protein kinase C. B) Binding of a hormone to a receptor must signal the exchange of GDP for GTP.

C) Binding of GTP to the receptor protein must induce a change in conformation of the receptor. D) Binding of cAMP to the α subunit of the G protein must initiate translocation of the subunit. The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.

Am J. Previous studies have reported abnormalities either in the cAMP-dependent endogenous phosphorylation or in the levels of Rap1 in platelets from bipolar patients.

One limitation of these findings was that they come from different groups of patients in independent studies. To overcome this limitation, we designed the present study in which both these biochemicals parameters were assessed in the.

This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and.Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability Specialty: Psychiatry.THE JOURNAL OF BIOLOGICAL CHEMISTRY Q by The American Society for Biochemistry and Molecular Biology, Inc.

Vol.No. 24, Issue of Aug pp.Printed in U.S.A. Localization of the CAMP-dependent Protein Kinase to the Postsynaptic Densities by A-Kinase Anchoring Proteins.